Ralstonia pickettii and Pseudomonas aeruginosa Bloodstream Infections Associated with Contaminated Extracorporeal Membrane Oxygenation Water Heater Devices
Baker AM et al.Clinical Infectious Diseases May 2022
After tracking a rash of unusual infections, Brigham and Women’s Hospital’s infection control team called on epiXact, our rapid, whole-genome sequencing (WGS) service using single-nucleotide polymorphism analysis, to help trace outbreak strains of Burholderia, Ralstonia picketti and Pseudomonas aeruginosa. With the high resolution offered by WGS, the infection control team was able to conclusively link the outbreak with (ECMO) water heater devices which would have been otherwise challenging due to the prevalence of multiple species collected from various locations.
Cluster of Burkholderia cepacia Complex Infections Associated with Extracorporeal Membrane Oxygenation Water Heater Devices
Rhee et al. Clinical Infectious Diseases 2022 March.
Our epiXact healthcare-associated infection (HAI) service helped Brigham and Women’s hospital link a cluster of Burkholderia cepacia complex infections in cardiothoracic ICU patients to contaminated Extracorporeal Membrane Oxygenation Water Heater Devices.
Shiga Toxin–Producing Escherichia coli Transmission via Fecal Microbiota Transplant
Zellmer et al. Clinical Infectious Diseases 2021 June, Vol 72, Issue 11.
Our epiXact service for healthcare-associated infections (HAIs) confirmed the first known report of an undetected transmission of Shiga toxin-producing E. coli (STEC) in a fecal microbiota transplantation, despite enzyme-based STEC screening having been performed on donor samples. Following epiXact’s actionable findings, OpenBiome worked, in consultation with the FDA, to implement prospective PCR-based testing to enhance patient safety and avoid future transmissions.
Community-acquired in Name Only: A Cluster of Carbapenem-resistant Acinetobacter Baumannii in a Burn Intensive Care Unit and Beyond
Shenoy et al. Infection Control & Hospital Epidemiology 2020 May;41(5):531-538. doi.org/10.1017/ice.2020.15
Mass General Hospital used our epiXact service to rapidly identify and respond to a highly-resistant A. baumannii outbreak in an ICU burn unit that was initially believed to be caused by community-transmission.
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant
DeFilipp et al. The New England Journal of Medicine 2019 October.
Our epiXact service was used by Mass General Hospital to provide high-resolution whole-genome sequencing analysis in less than two days to help uncover the cause of the first known fecal matter transplant patient death.